Detalhe da pesquisa
1.
Discovery, biosynthesis, and engineering of lantipeptides.
Annu Rev Biochem
; 81: 479-505, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22404629
2.
Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry.
J Am Chem Soc
; 135(19): 7094-7, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23621626
3.
Optimization of peptide-based polyagonists for treatment of diabetes and obesity.
Bioorg Med Chem
; 26(10): 2873-2881, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29153547
4.
Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria.
Proc Natl Acad Sci U S A
; 107(23): 10430-5, 2010 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20479271
5.
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.
Nat Metab
; 5(12): 2075-2085, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37946085
6.
Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X.
J Am Chem Soc
; 134(18): 7648-51, 2012 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22524291
7.
An engineered lantibiotic synthetase that does not require a leader peptide on its substrate.
J Am Chem Soc
; 134(16): 6952-5, 2012 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22480178
8.
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice.
Mol Metab
; 63: 101533, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35809773
9.
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems.
Mol Metab
; 66: 101638, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36400403
10.
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
Nat Metab
; 4(8): 1071-1083, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35995995
11.
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.
Mol Metab
; 49: 101181, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556643
12.
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.
Cell Metab
; 33(4): 833-844.e5, 2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33571454
13.
Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates.
Peptides
; 125: 170225, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31786282
14.
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids.
J Am Chem Soc
; 131(34): 12024-5, 2009 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19655738
15.
Zinc-triggered hydrogelation of a self-assembling ß-hairpin peptide.
Angew Chem Int Ed Engl
; 50(7): 1577-9, 2011 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21308908
16.
Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin.
ChemMedChem
; 9(10): 2223-6, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25056114
17.
Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation.
ACS Chem Biol
; 7(11): 1791-5, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22920239
18.
Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin.
ACS Chem Biol
; 6(7): 753-60, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21520911